301 Combatting melioidosis with chemical synthetic lethality
https://www.pnas.org/doi/10.1073/pnas.2406771121
300 Metformin decelerates aging clock in male monkeys
https://www.cell.com/cell/abstract/S0092-8674(24)00914-0
299 Glucose-sensitive insulin with attenuation of hypoglycaemia
https://www.nature.com/articles/s41586-024-08042-3
298 Insulin-inspired hippocampal neuron–targeting technology for protein drug delivery
https://www.pnas.org/doi/10.1073/pnas.2407936121
297 Sympathetic neuropeptide Y protects from obesity by sustaining thermogenic fat
https://www.nature.com/articles/s41586-024-07863-6
296 Metformin decelerates aging clock in male monkeys
https://www.sciencedirect.com/science/article/abs/pii/S0092867424009140?via%3Dihub
295 A general strategy for the synthesis of taxane diterpenes
https://www.nature.com/articles/s41586-024-07675-8
294 Semisynthetic guanidino lipoglycopeptides with potent in vitro and in vivo antibacterial activity
https://www.science.org/doi/10.1126/scitranslmed.abo4736
293 Piplartine attenuates aminoglycoside-induced TRPV1 activity and protects from hearing loss in mice
https://www.science.org/doi/10.1126/scitranslmed.adn2140
292 Early metformin treatment: An effective approach for targeting fragile X syndrome pathophysiology
https://www.pnas.org/doi/10.1073/pnas.2407546121
291 PhAI: A deep-learning approach to solve the crystallographic phase problem
https://www.science.org/doi/10.1126/science.adn2777
290 A Gram-negative-selective antibiotic that spares the gut microbiome
https://www.nature.com/articles/s41586-024-07502-0
289 Accelerating diabetic wound healing by ROS-scavenging lipid nanoparticle–mRNA formulation
https://www.pnas.org/doi/10.1073/pnas.2322935121
288 GLP-1-directed NMDA receptor antagonism for obesity treatment
https://www.nature.com/articles/s41586-024-07419-8
287 Strategy to develop broadly effective multivalent COVID-19 vaccines against emerging variants based on Ad5/35 platform
https://www.pnas.org/doi/10.1073/pnas.2313681121
286 Oral administration of obeldesivir protects nonhuman primates against Sudan ebolavirus
https://www.science.org/doi/10.1126/science.adk6176
285 Antibacterial activity of nonantibiotics is orthogonal to standard antibiotics
https://www.science.org/doi/10.1126/science.adk7368
284 Discovery of a structural class of antibiotics with explainable deep learning
https://www.nature.com/articles/s41586-023-06887-8
283 Boosting systemic absorption of peptides with a bioinspired buccal-stretching patch.
https://www.science.org/doi/10.1126/scitranslmed.abq1887
282 An antibiotic from an uncultured bacterium binds to an immutable target.
https://www.cell.com/cell/fulltext/S0092-8674(23)00853-X
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