281 Farnesol prevents aging-related muscle weakness in mice through enhanced farnesylation of Parkin-interacting substrate.
https://www.science.org/doi/10.1126/scitranslmed.abh3489
280 Self-powered, light-controlled, bioresorbable platforms for programmed drug delivery.
https://www.pnas.org/doi/10.1073/pnas.2217734120
279 A synthetic porphyrin as an effective dual antidote against carbon monoxide and cyanide poisoning.
https://www.pnas.org/doi/10.1073/pnas.2209924120
278 Terpene biosynthesis in marine sponge animals.
https://www.pnas.org/doi/10.1073/pnas.2220934120
277 Metformin acts in the gut and induces gut-liver crosstalk.
https://www.pnas.org/doi/10.1073/pnas.2211933120
276 Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.
https://www.science.org/doi/10.1126/sciadv.abq5925
275 Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.
https://www.nature.com/articles/s41587-022-01334-x
274 A small-molecule compound may help in the development of rapidly acting antidepressants by regulating the firing of serotonergic neurons.
https://www.science.org/doi/10.1126/science.abo3566
273 A high-throughput virtual screen followed by experimental testing generates therapeutic leads for non-opioid pain killers.
https://www.science.org/doi/10.1126/science.abn7065
272 Tirzepatide Once Weekly for the Treatment of Obesity.
https://www.nejm.org/doi/full/10.1056/NEJMoa2206038?query=featured_home
271 Light-activated molecular machines are fast-acting broad-spectrum antibacterials that target the membrane.
https://www.science.org/doi/10.1126/sciadv.abm2055
270 Computer-designed repurposing of chemical wastes into drugs.
https://www.nature.com/articles/s41586-022-04503-9
269 Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring.
https://www.acpjournals.org/doi/10.7326/M21-4389
268 Two Phase 3 Trials of Baricitinib for Alopecia Areata.
https://www.nejm.org/doi/full/10.1056/NEJMoa2110343?query=featured_home
267 Bacterioboat is a good bacteria-based oral drug delivery tool that enhances drug efficacy and potency and makes drugs safer.
https://www.science.org/doi/10.1126/sciadv.abh1419
266 Glutamine promotes antibiotic uptake to kill multidrug-resistant uropathogenic bacteria.
https://www.science.org/doi/10.1126/scitranslmed.abj0716
265 An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
https://www.science.org/doi/10.1126/science.abl4784
264 Rational design of a new antibiotic class for drug-resistant infections.
https://www.nature.com/articles/s41586-021-03899-0
263 A repurposing screen identifies the orally available drug masitinib as able to inhibit virus replication in mouse-based models of COVID-19.
https://science.sciencemag.org/content/373/6557/931
262 The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance.
https://stm.sciencemag.org/content/13/603/eabg6013
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