77  Interferon-induced APOL3 is a detergent-like protein that kills cytosolic pathogens to protect human cells against infection.

76  Data storage using peptide sequences.

75  Computationally designed proteins assemble antibodies into precise and potent nanostructures.

74  The mosquito protein AEG12 displays both cytolytic and antiviral properties via a common lipid transfer mechanism.

73  The intracellular environment affects protein–protein interactions.

72  A versatile platform reprograms botulinum neurotoxin proteases to selectively cleave proteins of biomedical interest in vitro and in neurons.

71  Successful de novo design of transmembrane β-barrel proteins provides insight into the principles that guide their folding.

70  DeepTFactor: A deep learning-based tool for the prediction of transcription factors.

69  The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease.

68  Structures of the acetohydroxyacid synthase complexes of Saccharomyces cerevisiae and Arabidopsis thaliana provide insights into the biosynthesis of and feedback inhibition by branched-chain amino acids.

67  ROR2 blockade improves the functional and structural outcomes of osteoarthritis in preclinical animal models by inhibiting YAP signaling.

66  In a mouse model of the leukodystrophy Pelizaeus–Merzbacher disease, myelination, motor performance, respiratory function and lifespan are improved by suppressing proteolipid protein expression, suggesting PLP1 as a therapeutic target for human patients with this disease and, more broadly, antisense oligonucleotides as a pharmaceutical modality for treatment of myelin disorders.

65  An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen.

64  Primordial emergence of a nucleic acid-binding protein via phase separation and statistical ornithine-to-arginine conversion.

63  A conserved protein kinase VRK-1 increases life span by activating a key energy sensor AMPK in the roundworm C. elegans.

62  The proteome landscape of the kingdoms of life.

61  A compound that disassembles the circadian repressive super-complex can reset circadian phase and relieve jet lag in mice.

60  A human binary protein interactome map that includes around 53,000 protein–protein interactions involving more than 8,000 proteins provides a reference for the study of human cellular function in health and disease.

59  FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis.

58  The enzymatic activity of caspase-8 controls apoptosis, necroptosis and pyroptosis, and prevents tissue damage during embryonic development and adulthood in mice.

Free Images for Presentation: sunipix SUNIPIX