857 Inactivation of a chromatin remodeling complex in tumor cells enhances their sensitivity to killing by T cells.
http://science.sciencemag.org/content/359/6377/770
856 Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury.
https://www.nature.com/articles/nm.4470
855 Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models.
https://www.nature.com/articles/nm.4464
854 A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.
https://www.nature.com/articles/nm.4474
853 Targeting IRF3 as a YAP agonist therapy against gastric cancer.
http://jem.rupress.org/content/215/2/699
852 Asparagine bioavailability governs metastasis in a model of breast cancer.
https://www.nature.com/articles/nature25465
851 Targeting of p53- and PUMA-dependent apoptosis protects intestinal stem cells, but not cancer cells, against chemotherapy.
http://stm.sciencemag.org/content/10/427/eaam7610
850 HER kinase inhibition in patients with HER2- and HER3-mutant cancers.
https://www.nature.com/articles/nature25475
849 Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria.
http://science.sciencemag.org/content/359/6375/592
848 Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy.
http://science.sciencemag.org/content/359/6375/582
847 Eradication of spontaneous malignancy by local immunotherapy.
http://stm.sciencemag.org/content/10/426/eaan4488
846 Elevated d-2-hydroxyglutarate during colitis drives progression to colorectal cancer.
http://www.pnas.org/content/115/5/1057
845 Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells.
https://www.nature.com/articles/s41467-018-02865-1
844 Detection and localization of surgically resectable cancers with a multi-analyte blood test.
http://science.sciencemag.org/content/early/2018/01/17/science.aar3247
843 Identifying DNA methylation biomarkers for non-endoscopic detection of Barrett’s esophagus.
http://stm.sciencemag.org/content/10/424/eaao5848
842 Rapid drug screen using 3D tumor organoids.
http://stm.sciencemag.org/content/10/423/eaar7507
841 Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade.
http://stm.sciencemag.org/content/10/422/eaam7577
840 Neoadjuvant oncolytic virotherapy before surgery sensitizes triple-negative breast cancer to immune checkpoint therapy.
http://stm.sciencemag.org/content/10/422/eaao1641
839 The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients.
http://science.sciencemag.org/content/359/6371/104
838 Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients.
http://science.sciencemag.org/content/359/6371/97
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