321 De novo design of a peptide modulator to reverse sodium channel dysfunction linked to cardiac arrhythmias and epilepsy
https://www.cell.com/cell/fulltext/S0092-8674(25)00860-8
320 Synthetic bottlebrush block copolymer prevents disease onset in Duchenne muscular dystrophy
https://www.pnas.org/doi/10.1073/pnas.2513599122
319 A generative deep learning approach to de novo antibiotic design
https://www.cell.com/cell/abstract/S0092-8674(25)00855-4
318 Engineering a highly selective, hemoprotein-based scavenger as a carbon monoxide poisoning antidote with no hypertensive effect
https://www.pnas.org/doi/10.1073/pnas.2501389122
317 Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III
https://www.nature.com/articles/s41586-025-09090-z
316 Targeting ryanodine receptors with allopurinol and xanthine derivatives for the treatment of cardiac and musculoskeletal weakness disorders
https://www.pnas.org/doi/10.1073/pnas.2422082122
315 Snake venom protection by a cocktail of varespladib and broadly neutralizing human antibodies
https://www.cell.com/cell/abstract/S0092-8674(25)00402-7
314 Bespoke plant glycoconjugates for gut microbiota–mediated drug targeting
https://www.science.org/doi/10.1126/science.adk7633
313 Elucidation of the final steps in Taxol biosynthesis and its biotechnological production
https://www.nature.com/articles/s44160-025-00800-z
312 A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome
https://www.nature.com/articles/s41586-025-08723-7
311 Engineered commensals for targeted nose-to-brain drug delivery
https://www.cell.com/cell/fulltext/S0092-8674(25)00046-7
310 HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity
https://www.cell.com/cell/fulltext/S0092-8674(25)00098-4
309 Nav1.8, an analgesic target for nonpsychotomimetic phytocannabinoids
https://www.pnas.org/doi/10.1073/pnas.2416886122
308 Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy
https://www.science.org/doi/10.1126/scitranslmed.adk3690
307 Multiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target
https://www.sciencedirect.com/science/article/abs/pii/S0092867424010924
306 The Parkinson’s disease drug entacapone disrupts gut microbiome homeostasis via iron sequestration
https://www.nature.com/articles/s41564-024-01853-0
305 Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma
https://www.nature.com/articles/s41586-024-08224-z
304 Spatial proteomics identifies JAKi as treatment for a lethal skin disease
https://www.nature.com/articles/s41586-024-08061-0
303 Delayed low-dose oral administration of 4′-fluorouridine inhibits pathogenic arenaviruses in animal models of lethal disease
https://www.science.org/doi/10.1126/scitranslmed.ado7034
302 The limitation of lipidation: Conversion of semaglutide from once-weekly to once-monthly dosing
https://www.pnas.org/doi/10.1073/pnas.2415815121
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