493 Quiescent CD4 T cells in lymphoid tissues are shown to die after HIV-1 infection by caspase-1-mediated pyroptosis, a highly inflammatory form of programmed cell death; caspase 1 inhibitors, which are safe for human use, can rescue the cell death in vitro raising the possibility of new therapeutics targeting the host instead of the virus.
http://www.nature.com/nature/journal/v505/n7484/full/nature12940.html
492 The analysis of multiple SIV vaccine regimens in macaques leads to the identification of a key two-amino-acid signature that confers resistance to neutralizing antibodies; a similar mechanism of immune escape is shown to operate in HIV and may explain the limited efficacy seen in HIV vaccine trials.
http://www.nature.com/nature/journal/v505/n7484/full/nature12893.html
491 Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis.
http://www.cell.com/immunity/abstract/S1074-7613(13)00564-5
490 Induction of Innate Lymphoid Cell-Derived Interleukin-22 by the Transcription Factor STAT3 Mediates Protection against Intestinal Infection.
http://www.cell.com/immunity/abstract/S1074-7613(13)00555-4
489 Sphingolipids from a Symbiotic Microbe Regulate Homeostasis of Host Intestinal Natural Killer T Cells.
http://www.cell.com/abstract/S0092-8674(13)01528-6
488 Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing.
http://www.cell.com/abstract/S0092-8674(13)01545-6
487 Aberrant activation of human TH9 cells may contribute to inflammatory diseases of the skin.
http://stm.sciencemag.org/content/6/219/219ra8.abstract
486 Negatively charged immune-modifying microparticles bind to the scavenger receptor MARCO on inflammatory monocytes, resulting in their apoptosis and reduced inflammatory damage in a range of diseases.
http://stm.sciencemag.org/content/6/219/219ra7.abstract
485 The airway mucin Muc5b (but not Muc5ac) is required for mucociliary clearance, defence against bacterial infection in the airways and middle ear, and maintenance of immune homeostasis in the lungs; Muc5b deficiency causes accumulation of apoptotic macrophages, impairment of phagocytosis and reduced production of interleukin-23, leading to infection and inflammation.
http://www.nature.com/nature/journal/v505/n7483/full/nature12807.html
484 The success of the yellow fever vaccine is linked to the amino acid starvation pathway, which promotes adaptive immunity.
http://www.sciencemag.org/content/343/6168/313.abstract
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