318 Patients with sickle cell disease or β-thalassemia are treated with drugs that aim to reactivate production of fetal hemoglobin, but these drugs are not effective in all patients and have side effects. Lihong Shi et al. identify a new therapeutic strategy for these anemias, showing that a drug used to treat depression, tranylcypromine, can raise fetal hemoglobin levels in human erythroid cells and transgenic mice harboring the human β-globin locus, most likely by inhibiting a lysine demethylas
http://www.nature.com/nm/journal/v19/n3/abs/nm.3101.html
317 The cytokine interferon-ε is expressed in the female reproductive tract and protects against sexually transmitted diseases.
http://www.sciencemag.org/content/339/6123/1088.abstract
316 Genomic responses in mouse models poorly mimic human inflammatory diseases.
http://www.pnas.org/content/110/9/3507.abstract
315 Angiotensin II Drives the Production of Tumor-Promoting Macrophages.
http://www.cell.com/immunity/abstract/S1074-7613(13)00003-4
314 Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps.
http://www.cell.com/cell-host-microbe/abstract/S1931-3128(13)00036-X
313 Mucosal vaccination induces targeted CD8+ T cell homing to inhibit mucosal tumors.
http://stm.sciencemag.org/content/5/172/172ra20.abstract
312 Involvement of Toso in activation of monocytes, macrophages, and granulocytes.
http://www.pnas.org/content/110/7/2593.abstract
311 Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production.
http://jem.rupress.org/content/210/1/143.abstract
310 LECT2 protects mice against bacterial sepsis by activating macrophages via the CD209a receptor.
http://jem.rupress.org/content/210/1/5.abstract
309 Complement provides costimulatory signals to T cells. In the absence of complement signaling in naive T cells it generates an autoinductive loop to drive induced regulatory T cells.
http://www.nature.com/ni/journal/v14/n2/abs/ni.2499.html
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