1175 Chimeric antigen receptor (CAR) T cells engineered to overexpress the canonical AP-1 transcription factor c-Jun are resistant to T cell exhaustion, and provide enhanced therapeutic benefit in mouse tumour models.
https://www.nature.com/articles/s41586-019-1805-z
1174 A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses.
https://science.sciencemag.org/content/366/6470/eaax4380
1173 Screening of a library of bile acid metabolites revealed two derivatives of lithocholic acid that act as regulators of T helper cells that express IL-17a and regulatory T cells, thus influencing host immune responses.
https://www.nature.com/articles/s41586-019-1785-z
1172 A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery.
https://www.pnas.org/content/116/49/24500
1171 Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation.
https://www.nature.com/articles/s43018-019-0004-z
1170 Activated leukocyte cell adhesion molecule regulates B lymphocyte migration across central nervous system barriers.
https://stm.sciencemag.org/content/11/518/eaaw0475
1169 Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens.
https://science.sciencemag.org/content/366/6465/599?_ga=2.93963227.716164128.1572536275-1271019578.1572536275
1168 In neonatal mice, microbial small molecules presented in the thymus drive the expansion of mucosal-associated invariant T cells.
https://science.sciencemag.org/content/366/6464/eaax6624
1167 High Glucose Intake Exacerbates Autoimmunity through Reactive-Oxygen-Species-Mediated TGF-β Cytokine Activation.
https://www.cell.com/immunity/fulltext/S1074-7613(19)30327-9
1166 An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
https://www.cell.com/cell/fulltext/S0092-8674(19)31015-3
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