1027 Combination cancer immunotherapy targeting PD-1 and GITR can rescue CD8+ T cell dysfunction and maintain memory phenotype.
http://immunology.sciencemag.org/content/3/29/eaat7061
1026 T cell receptor–triggered nuclear actin network formation drives CD4+ T cell effector functions.
http://immunology.sciencemag.org/content/4/31/eaav1987
1025 Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity.
https://www.nature.com/articles/s41586-018-0806-7
1024 Impaired immune surveillance accelerates accumulation of senescent cells and aging.
https://www.nature.com/articles/s41467-018-07825-3#ref-CR67
1023 Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function.
https://www.cell.com/cell/fulltext/S0092-8674(18)31333-3
1022 Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells.
https://www.cell.com/cell/fulltext/S0092-8674(18)31322-9
1021 Protein kinase p38α signaling in dendritic cells regulates colon inflammation and tumorigenesis.
https://www.pnas.org/content/115/52/E12313
1020 Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice.
https://www.pnas.org/content/115/52/13347
1019 MEK inhibition enhances oncolytic virus immunotherapy through increased tumor cell killing and T cell activation.
http://stm.sciencemag.org/content/10/471/eaau0417
1018 High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes.
http://science.sciencemag.org/content/362/6420/1306
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