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83 An insect virus gene controls the behavior of the dying host to increase dispersion of the virus. Gypsy moths infected by a baculovirus climb to the top of trees to die, liquefy, and “rain” virus on the foliage below to infect new hosts. The viral gene that manipulates climbing behavior of the host was identified, providing evidence of a genetic basis for the extended phenotype. Hoover K. et al. (2011). Science 333:1401.
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82 Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells. Toller IM. et al. (2011). PNAS 108:14944-14949.
http://www.pnas.org/content/108/36/14944.abstract
81 Recombinant Rift Valley fever vaccines induce protective levels of antibody in baboons and resistance to lethal challenge in mice. Papin JF. et al. (2011). PNAS 108: 14926-14931.
http://www.pnas.org/content/108/36/14926.abstract
80 Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Zhao B. et al. (2011). PNAS 108:14902-14907.
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79 Identification of nucleolin as a cellular receptor for human respiratory syncytial virus. Tayyari F. et al. (2011). Nature Medicine 17:1132-1135.
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78 Clostridium difficile causes serious intestinal illness mediated by two exotoxins, TcdA and TcdB. Savidge et al. report that these toxins can be modified by S-nitrosothiol, resulting in their impaired enzymatic activity in vitro and reduced disease in mice. Their findings suggest that promoting S-nitrosylation of C. difficile toxins may have therapeutic potential. Savidge TC. et al. (2011). Nature Medicine 17:1136-1141.
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77 CD8+ cellular immunity mediates rAd5 vaccine protection against Ebola virus infection of nonhuman primates. Sullivan NJ. et al. (2011). Nature Medicine 17:1128-1131.
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76 The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ. Ma F. et al. (2011). Nature Immunol. 12:861-869.
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75 Recruitment of the Major Vault Protein by InlK: A Listeria monocytogenes Strategy to Avoid Autophagy. Dortet L. et al. (2011).PLoS Pathog 7(8): e1002168.
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