144 Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing.
http://www.pnas.org/content/109/6/1919.abstract
143 Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells.
http://www.nature.com/ncb/journal/v14/n2/abs/ncb2422.html
142 New methods for analyzing ligand-receptor binding under physiologic conditions in cell-based assays and living animals are much needed for the testing and validation of candidate therapeutic agents targeting ligand-receptor binding. Here, Kathryn Luker and her colleagues developed a molecular imaging assay for ligand-receptor binding based on Gaussia luciferase complementation, focusing on chemokine CXCL12 and its chemokine receptors CXCR4 and CXCR7, although the assay could be applied more broa
http://www.nature.com/nm/journal/v18/n1/abs/nm.2590.html
141 Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities.
http://www.nature.com/nature/journal/v482/n7383/full/nature10814.html
140 Applying next-generation sequencing to 42 infants with mitochondrial disease highlights both the potential and the challenge of using this technology in clinical diagnosis.
http://stm.sciencemag.org/content/4/118/118ra10.abstract
139 Forkhead transcription factor FoxA1 regulates sweat secretion through Bestrophin 2 anion channel and Na-K-Cl cotransporter 1.
http://www.pnas.org/content/109/4/1199.abstract
138 Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders.
http://www.pnas.org/content/109/4/1023.abstract
137 A transgenic mouse model for monitoring oxidative stress.
http://www.nature.com/srep/2012/120119/srep00229/full/srep00229.html
136 Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation.
http://www.pnas.org/content/109/3/841.abstract
135 Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin.
http://www.pnas.org/content/109/2/413.abstract
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