506 Screening in yeast yields an effective therapeutic for Parkinson’s patient–derived neuronal stem cells.
http://www.sciencemag.org/content/342/6161/979.abstract
505 Introduction of different APOE isoforms modulates Aβ peptide aggregation and neurotoxicity after amyloid deposition in mouse brain.
http://stm.sciencemag.org/content/5/212/212ra161.abstract
504 X-linked microtubule-associated protein, Mid1, regulates axon development
http://www.pnas.org/content/110/47/19131.abstract
503 Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration.
http://www.pnas.org/content/110/47/E4530.abstract
502 Long-term depression triggers the selective elimination of weakly integrated synapses.
http://www.pnas.org/content/110/47/E4510.abstract
501 Genetic basis of neurocognitive decline and reduced white-matter integrity in normal human brain aging.
http://www.pnas.org/content/110/47/19006.abstract
500 Pulvinar neurons reveal neurobiological evidence of past selection for rapid detection of snakes.
http://www.pnas.org/content/110/47/19000
499 Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder.
http://www.nature.com/ncomms/2013/131119/ncomms3739/full/ncomms3739.html
498 Deletions of chromosome 22q13.3 cause Phelan–McDermid syndrome (PMDS), a neurodevelopmental disorder associated with autism; here induced pluripotent stem cells from PMDS patients with autism are used to produce neurons, they are shown to have reduced SHANK3 expression and a defect in excitatory synaptic transmission which can be restored either by increasing SHANK3 or with insulin-like growth factor 1.
http://www.nature.com/nature/journal/v503/n7475/full/nature12618.html
497 High-speed laser microsurgery of alert fruit flies for fluorescence imaging of neural activity.
http://www.pnas.org/content/110/46/18374.abstract
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