164 Treatment of otitis media by transtympanic delivery of antibiotics.
http://stm.sciencemag.org/content/8/356/356ra120
163 A selective inhibitor of the kinetoplastid proteasome (GNF6702) is identified that is highly efficacious in vivo, clearing the parasites that cause leishmaniasis, Chagas disease and sleeping sickness from mice, highlighting the possibility of developing a single class of drugs for these neglected diseases.
http://www.nature.com/nature/journal/v537/n7619/full/nature19339.html
162 Like citrate, the molecule hydroxycitrate is shown to inhibit growth of the crystal that is the principal component of kidney stones, suggesting that hydroxycitrate could be another treatment for kidney stone disease.
http://www.nature.com/nature/journal/v536/n7617/full/nature19062.html
161 Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors.
http://www.nature.com/ncomms/2016/160801/ncomms12348/full/ncomms12348.html
160 Novel cell-free high-throughput screening method for pharmacological tools targeting K+ channels.
http://www.pnas.org/content/113/20/5748
159 Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma.
http://www.pnas.org/content/113/17/E2355.abstract
158 Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis.
http://www.pnas.org/content/113/15/3960.abstract
157 On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system.
http://science.sciencemag.org/content/352/6281/61
156 Precision multidimensional assay for high-throughput microRNA drug discovery.
http://www.nature.com/ncomms/2016/160216/ncomms10709/full/ncomms10709.html
155 Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway.
http://www.nature.com/ncomms/2016/160216/ncomms10710/full/ncomms10710.html
154 Long-acting cocaine hydrolase for addiction therapy.
http://www.pnas.org/content/113/2/422.abstract
153 BRD4 is a novel therapeutic target for liver fibrosis.
http://www.pnas.org/content/112/51/15713.abstract
152 Implantable synthetic cytokine converter cells with AND-gate logic treat experimental psoriasis.
http://stm.sciencemag.org/content/7/318/318ra201
151 Structural studies give insight into how a human sodium channel involved in pain perception can be selectively inhibited.
http://www.sciencemag.org/content/350/6267/aac5464.abstract
150 Yeast-based screening identifies the benzodiazepine drug lorazepam as a non-selective positive allosteric modulator of the G-protein-coupled receptor (GPCR) GPR68; homology modelling and molecular docking of 3.1 million molecules found a new compound, ‘ogerin’, as a potent GPR68 modulator, which suppressed recall in fear conditioning in wild-type mice, and the general method of combining physical and structure-based screening may lead to the discovery of selective ligands for other GPCRs.
http://www.nature.com/nature/journal/v527/n7579/full/nature15699.html
149 Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle.
http://stm.sciencemag.org/content/7/314/314ra183
148 A compound that reverses the molecular cause of cataract formation improves eye lens transparency in mice.
http://www.sciencemag.org/content/350/6261/674.abstract
147 Helical antimicrobial polypeptides with radial amphiphilicity.
http://www.pnas.org/content/112/43/13155.abstract
146 Broad and efficient control of major foodborne pathogenic strains of Escherichia coli by mixtures of plant-produced colicins.
http://www.pnas.org/content/112/40/E5454
145 Idarucizumab for Dabigatran Reversal.
http://www.nejm.org/doi/full/10.1056/NEJMoa1502000
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