49 The plasmodium protein kinase PfCLK3 provides a specific protein kinase target for antimalarial development.
https://science.sciencemag.org/content/365/6456/eaau1682
48 Compendium of 4,941 rumen metagenome-assembled genomes for rumen microbiome biology and enzyme discovery.
https://www.nature.com/articles/s41587-019-0202-3
47 Cholera toxin promotes pathogen acquisition of host-derived nutrients.
https://www.nature.com/articles/s41586-019-1453-3
46 A technique for the de novo design of switchable protein systems controlled by induced conformational change is demonstrated for three functional motifs, in vitro and in yeast and mammalian cells.
https://www.nature.com/articles/s41586-019-1432-8
45 Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
https://stm.sciencemag.org/content/11/500/eaav5464
44 Allosteric modulation of a human protein kinase with monobodies.
https://www.pnas.org/content/116/28/13937
43 In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation.
https://www.pnas.org/content/116/23/11490
42 SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.
https://www.cell.com/cell/fulltext/S0092-8674(19)30344-7
41 TePhe, a tellurium-containing phenylalanine mimic, allows monitoring of protein synthesis in vivo with mass cytometry.
https://www.pnas.org/content/116/17/8155
40 Critical role of spectrin in hearing development and deafness.
https://advances.sciencemag.org/content/5/4/eaav7803
39 Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma.
https://www.nature.com/articles/s41586-019-0993-x
38 The centrosome protein AKNA regulates neurogenesis via microtubule organization.
https://www.nature.com/articles/s41586-019-0962-4
37 Microbiome-derived nitric oxide causes widespread post-translational modification of host proteins to regulate host functions and physiology.
https://www.cell.com/cell/fulltext/S0092-8674(19)30100-X
36 Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.
https://www.pnas.org/content/116/7/2545
35 IPSE, a urogenital parasite-derived immunomodulatory protein, ameliorates ifosfamide-induced hemorrhagic cystitis through downregulation of pro-inflammatory pathways.
https://www.nature.com/articles/s41598-018-38274-z
34 Anthrax toxin requires ZDHHC5-mediated palmitoylation of its surface-processing host enzymes.
https://www.pnas.org/content/116/4/1279
33 Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases.
https://www.pnas.org/content/116/3/970
32 Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo.
https://www.pnas.org/content/116/3/960
31 Computational design incorporating modular buried hydrogen networks produces highly orthogonal protein heterodimers.
https://www.nature.com/articles/s41586-018-0802-y
30 A method for encoding the non-canonical amino acid 2,3-diaminopropionate into proteins allows key acyl intermediates in the biosynthesis of valinomycin to be trapped, providing insight into the oligomerization and cyclization reactions involved.
https://www.nature.com/articles/s41586-018-0781-z
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