129 Structure of the cold- and menthol-sensing ion channel TRPM8.
http://science.sciencemag.org/content/359/6372/237
128 High-resolution D4 dopamine receptor crystal structures facilitate the discovery of new ligands.
http://science.sciencemag.org/content/358/6361/381
127 The crystal structure of the bacterial potassium import complex KdpFABC shows how ATP hydrolysis is coupled to potassium transport to maintain cellular homeostasis under low potassium conditions.
http://www.nature.com/nature/journal/v546/n7660/full/nature22970.html
126 Structure of the Human Lipid Exporter ABCA1.
http://www.cell.com/cell/fulltext/S0092-8674(17)30580-9
125 Structure and function of the Zika virus full-length NS5 protein.
http://www.nature.com/articles/ncomms14762
124 Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution.
http://science.sciencemag.org/content/355/6328/eaal4326
123 Crystal Structure of an LSD-Bound Human Serotonin Receptor.
http://www.cell.com/cell/fulltext/S0092-8674(16)31749-4
122 Principles for designing proteins with cavities formed by curved β sheets.
http://science.sciencemag.org/content/355/6321/201
121 Crystal structure of unlinked NS2B-NS3 protease from Zika virus.
http://science.sciencemag.org/content/354/6319/1597
120 Atomic model for the membrane-embedded VO motor of a eukaryotic V-ATPase.
http://www.nature.com/nature/journal/v539/n7627/full/nature19828.html
119 X-ray structure of the human α4β2 nicotinic receptor.
http://www.nature.com/nature/journal/v538/n7625/full/nature19785.html
118 Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs.
http://www.nature.com/nature/journal/v537/n7618/full/nature19102.html
117 Structure of the STRA6 receptor for retinol uptake.
http://science.sciencemag.org/content/353/6302/aad8266
116 Structure of mammalian respiratory complex I.
http://www.nature.com/nature/journal/v536/n7616/full/nature19095.html
115 Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor.
http://science.sciencemag.org/content/353/6298/503
114 Crystal structure of the epithelial calcium channel TRPV6.
http://www.nature.com/nature/journal/v534/n7608/full/nature17975.html
113 Extra-helical binding site of a glucagon receptor antagonist.
http://www.nature.com/nature/journal/v533/n7602/full/nature17414.html
112 The crystal structure of Cpf1 in complex with CRISPR RNA.
http://www.nature.com/nature/journal/v532/n7600/full/nature17944.html
111 X-ray crystal structures of the human serotonin transporter (SERT) bound to the antidepressants (S)-citalopram or paroxetine show that the antidepressants lock the protein in an outward-open conformation, and directly block serotonin from entering its binding site; the structures define the mechanism of antidepressant action in SERT and pave the way for future drug design.
http://www.nature.com/nature/journal/v532/n7599/full/nature17629.html
110 Reconstitution, spectroscopy, and crystallography allow the construction of a model of the human nuclear pore.
http://science.sciencemag.org/content/352/6283/363.abstract
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