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http://www.pnas.org/content/108/27/10952
5 Direct visualization at the single-cell level of siRNA electrotransfer into cancer cells. Gioanni AP et al. (2011). PNAS 108: 10443-10447.
http://www.pnas.org/content/108/26/10443.abstract
4 Fluorescent peptides highlight peripheral nerves during surgery in mice. Whitney MA. et al. (2011). Nature Biotechnology 29:352–356.
http://www.nature.com/nbt/journal/v29/n4/abs/nbt.1764.html
3 The first viable rat-mouse chimeras demonstrate that rat induced pluripotent stem (iPS) cells can rescue organ deficiency in mice. Rat iPS cells formed a fully functional pancreas when injected into mouse blastocysts lacking the Pdx1 gene required for pancreas formation.
Kobayashi T . et al. (2010) Cell 142:787-799.
http://www.cell.com/abstract/S0092-8674(10)00843-3
2 To identify genes affecting traits of interest in E. coli, Warner et al. describe a method to rapidly create and assay rationally mutated versions of every gene. The approach is applied to several traits, including tolerance to cellulosic hydrolysate, a biofuel precursor.
Warner JR. (2010). Nature Biotechnology 28: 856-862.
http://www.nature.com/nbt/journal/v28/n8/abs/nbt.1653.html
1 Harald Ott and his colleagues develop a new way to bioengineer a functioning lung. Through a process of decellularization, seeding with endothelial and epithelial cells, and maturation in an innovative bioreactor system, followed by transplantation into rats of the regenerated lungs in orthotopic position, the group was able to demonstrate adequate ventilation, blood flow and gas exchange in vivo for short periods of time.
Ott HC. et al. (2010). Nature Medicine 16: 927-933.
http://www.nature.com/nm/journal/v16/n8/abs/nm.2193.html
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