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11 Allergies to nickel are the most frequent cause of contact hypersensitivity in industrialized countries. Nickel induces an inflammatory response via direct activation of human Toll-like receptor 4.
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8 A costimulatory receptor for immune cells in the skin is identified.
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7 Repeated vaccination of mice with bacille Calmette-Guérin after Mycobacteriun infection results in increased IL-17, tumor necrosis factor, IL-6, and MIP-2 expression, influx of granulocytes/neutrophils, and lung tissue damage.
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4 Low-dose IL-2 can reverse established Type 1 diabetes in a mouse model. Grinberg-Bleyer et al., J. Exp. Med. (2010) (in press)
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3 A transcription factor Bcl11b is essential for maintenance of T cell identity.
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