513 A system that targets DNA polymerase activity with CRISPR-guided nickases to provide genetic diversification at user-defined loci enables forward genetic approaches.
https://www.nature.com/articles/s41586-018-0384-8
512 Three-dimensional intact-tissue sequencing of single-cell transcriptional states.
http://science.sciencemag.org/content/361/6400/eaat5691
511 De novo DNA synthesis using polymerase-nucleotide conjugates.
https://www.nature.com/articles/Nbt.4173
510 Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice.
https://www.nature.com/articles/s41586-018-0162-7
509 Field-deployable viral diagnostics using CRISPR-Cas13.
http://science.sciencemag.org/content/360/6387/444
508 Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6.
http://science.sciencemag.org/content/360/6387/439
507 CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity.
http://science.sciencemag.org/content/360/6387/436
506 Identification of an ion channel that functions in sour taste sensation in mammals and flies is described.
http://science.sciencemag.org/content/359/6379/1047
505 Cryo-electron microscopy and single-molecule studies reveal that the adaptors BICDR1 and HOOK3 recruit two dynein molecules to dynactin and thereby increase the force and speed of the dynein–dynactin microtubule motor.
https://www.nature.com/articles/nature25462
504 Structure of the yeast oligosaccharyltransferase complex gives insight into eukaryotic N-glycosylation.
http://science.sciencemag.org/content/359/6375/545
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