4 The protein Arrestin is able to regulate IGF-1R signaling and longevity.
Palmitessa A and Benovic J.L. (2010). Arrestin and the Multi-PDZ Domain-containing Protein MPZ-1 Interact with Phosphatase and Tensin Homolog (PTEN) and Regulate Caenorhabditis elegans Longevity. 285, 15187-15200.
http://www.jbc.org/content/285/20/15187
3 Caspase activation cleaves tau to initiate tangle formation, then truncated tau recruits normal tau to misfold and form tangles. Soluble tau species, rather than fibrillar tau, may be the critical toxic moiety underlying neurodegeneration.
De Calignon et al. (2010) Nature 464, 1201-1204
http://www.nature.com/nature/journal/v464/n7292/abs/nature08890.html
2 Listeria monocytogenes induces degradation of one of the essential SUMOylation enzymes, Ubc9, through a mechanism that involves a bacterial toxin, listeriolysin O. This effect on SUMOylation may support efficient infection by Listeria.
Ribet et al. (2010) Nature 464, 1192-1195.
http://www.nature.com/nature/journal/v464/n7292/abs/nature08963.html
1 Eastern blotting, a technique to detect post-translational protein modification. The Hsp60 protein of the non-virulent Ehrlichia muris is more post-translationaly modified than the highly virulent IOE.
http://www.ncbi.nlm.nih.gov/pubmed/19493209
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