934 Decreased abundance of TRESK two-pore domain potassium channels in sensory neurons underlies the pain associated with bone metastasis.
http://stke.sciencemag.org/content/11/552/eaao5150
933 Local generation of hydrogen for enhanced photothermal therapy.
https://www.nature.com/articles/s41467-018-06630-2
932 BAP1 links metabolic regulation of ferroptosis to tumour suppression.
https://www.nature.com/articles/s41556-018-0178-0
931 Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy.
http://science.sciencemag.org/content/362/6411/eaar3593
930 SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer.
https://www.cell.com/immunity/fulltext/S1074-7613(18)30387-X
929 The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells.
https://www.cell.com/immunity/fulltext/S1074-7613(18)30381-9
928 Prostate and lung cancers convert to a drug-resistant, lethal form of cancer through the same reprogramming mechanism.
http://science.sciencemag.org/content/362/6410/91
927 Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex.
http://science.sciencemag.org/content/362/6410/eaas8843
926 Necroptosis microenvironment directs lineage commitment in liver cancer.
https://www.nature.com/articles/s41586-018-0519-y
925 Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice.
http://science.sciencemag.org/content/361/6409/eaao4227
924 mRNA vaccination with charge-altering releasable transporters elicits human T cell responses and cures established tumors in mice.
http://www.pnas.org/content/115/39/E9153
923 Precancerous neoplastic cells can move through the pancreatic ductal system.
https://www.nature.com/articles/s41586-018-0481-8
922 Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures.
https://www.cell.com/cell/fulltext/S0092-8674(18)30913-9
921 Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids.
https://www.cell.com/cell/fulltext/S0092-8674(18)30903-6
920 Genotype-targeted local therapy of glioma.
http://www.pnas.org/content/115/36/E8388
919 Classification of prostate cancer using a protease activity nanosensor library.
http://www.pnas.org/content/115/36/8954
918 The gene fusions driving sarcoma growth often arise by the formation of dramatic genomic loops that rearrange many genes.
http://science.sciencemag.org/content/361/6405/eaam8419
917 Glucose–insulin feedback can reactivate PI3K in tumours treated with PI3K inhibitors, reducing therapeutic efficacy, but this effect can be reduced by using drugs or diet to suppress the insulin response.
https://www.nature.com/articles/s41586-018-0343-4
916 KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice.
http://stm.sciencemag.org/content/10/454/eaar2718
915 Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors.
http://science.sciencemag.org/content/361/6402/594
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