Cancer Biology

1002 Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer.

1001 Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism.

1000 Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5−/− mice.

999 Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response.

998 Chimeric antigen receptors (CARs) promote antigen loss in tumour cells by trogocytosis, which results in T cell fratricide killing and exhaustion but can be counteracted by cooperative killing and combinatorial targeting.

997 Exogenous pyruvate is needed for breast cancer cells to form metastases, and the inhibition of pyruvate metabolism impairs collagen hydroxylation and the growth of lung metastases in different mouse models.

996 Deprivation of glutamine in cell culture reveals its potential for treating cancer.

995 GPRC5D is an attractive target for immunotherapy of myeloma, and optimized GPRC5D-targeted CAR T cells eradicate myeloma xenografts.

994 T cell stemness and dysfunction in tumors are triggered by a common mechanism.

993 NR4A transcription factors limit CAR T cell function in solid tumours.

992 Glucocorticoids promote breast cancer metastasis.

991 A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy.

990 A Highly Efficient Tumor‐Targeting Nanoprobe with a Novel Cell Membrane Permeability Mechanism.

989 Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma.

988 An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma.

987 Mutations that protect a small guanosine triphosphatase from its normal proteolytic degradation lead to excessive growth factor signaling.

986 Pancreatic cancer activates IL-6–STAT3 signalling in hepatocytes to induce the formation of a pro-metastatic niche in the liver.

985 Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth.

984 The authors find that loss of squalene monooxygenase expression alters the lipid metabolism of cancer cells, which confers protection from ferroptotic cell death and thus promotes tumour growth.

983 Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer.

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