290 A Gram-negative-selective antibiotic that spares the gut microbiome
https://www.nature.com/articles/s41586-024-07502-0
289 Accelerating diabetic wound healing by ROS-scavenging lipid nanoparticle–mRNA formulation
https://www.pnas.org/doi/10.1073/pnas.2322935121
288 GLP-1-directed NMDA receptor antagonism for obesity treatment
https://www.nature.com/articles/s41586-024-07419-8
287 Strategy to develop broadly effective multivalent COVID-19 vaccines against emerging variants based on Ad5/35 platform
https://www.pnas.org/doi/10.1073/pnas.2313681121
286 Oral administration of obeldesivir protects nonhuman primates against Sudan ebolavirus
https://www.science.org/doi/10.1126/science.adk6176
285 Antibacterial activity of nonantibiotics is orthogonal to standard antibiotics
https://www.science.org/doi/10.1126/science.adk7368
284 Discovery of a structural class of antibiotics with explainable deep learning
https://www.nature.com/articles/s41586-023-06887-8
283 Boosting systemic absorption of peptides with a bioinspired buccal-stretching patch.
https://www.science.org/doi/10.1126/scitranslmed.abq1887
282 An antibiotic from an uncultured bacterium binds to an immutable target.
https://www.cell.com/cell/fulltext/S0092-8674(23)00853-X
281 Farnesol prevents aging-related muscle weakness in mice through enhanced farnesylation of Parkin-interacting substrate.
https://www.science.org/doi/10.1126/scitranslmed.abh3489
280 Self-powered, light-controlled, bioresorbable platforms for programmed drug delivery.
https://www.pnas.org/doi/10.1073/pnas.2217734120
279 A synthetic porphyrin as an effective dual antidote against carbon monoxide and cyanide poisoning.
https://www.pnas.org/doi/10.1073/pnas.2209924120
278 Terpene biosynthesis in marine sponge animals.
https://www.pnas.org/doi/10.1073/pnas.2220934120
277 Metformin acts in the gut and induces gut-liver crosstalk.
https://www.pnas.org/doi/10.1073/pnas.2211933120
276 Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.
https://www.science.org/doi/10.1126/sciadv.abq5925
275 Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.
https://www.nature.com/articles/s41587-022-01334-x
274 A small-molecule compound may help in the development of rapidly acting antidepressants by regulating the firing of serotonergic neurons.
https://www.science.org/doi/10.1126/science.abo3566
273 A high-throughput virtual screen followed by experimental testing generates therapeutic leads for non-opioid pain killers.
https://www.science.org/doi/10.1126/science.abn7065
272 Tirzepatide Once Weekly for the Treatment of Obesity.
https://www.nejm.org/doi/full/10.1056/NEJMoa2206038?query=featured_home
271 Light-activated molecular machines are fast-acting broad-spectrum antibacterials that target the membrane.
https://www.science.org/doi/10.1126/sciadv.abm2055
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