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287 Strategy to develop broadly effective multivalent COVID-19 vaccines against emerging variants based on Ad5/35 platform

286 Oral administration of obeldesivir protects nonhuman primates against Sudan ebolavirus

285 Antibacterial activity of nonantibiotics is orthogonal to standard antibiotics

284 Discovery of a structural class of antibiotics with explainable deep learning

283 Boosting systemic absorption of peptides with a bioinspired buccal-stretching patch.

282 An antibiotic from an uncultured bacterium binds to an immutable target.

281 Farnesol prevents aging-related muscle weakness in mice through enhanced farnesylation of Parkin-interacting substrate.

280 Self-powered, light-controlled, bioresorbable platforms for programmed drug delivery.

279 A synthetic porphyrin as an effective dual antidote against carbon monoxide and cyanide poisoning.

278 Terpene biosynthesis in marine sponge animals.

277 Metformin acts in the gut and induces gut-liver crosstalk.

276 Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.

275 Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.

274 A small-molecule compound may help in the development of rapidly acting antidepressants by regulating the firing of serotonergic neurons.

273 A high-throughput virtual screen followed by experimental testing generates therapeutic leads for non-opioid pain killers.

272 Tirzepatide Once Weekly for the Treatment of Obesity.

271 Light-activated molecular machines are fast-acting broad-spectrum antibacterials that target the membrane.

270 Computer-designed repurposing of chemical wastes into drugs.

269 Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring.

268 Two Phase 3 Trials of Baricitinib for Alopecia Areata.

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