309 Nav1.8, an analgesic target for nonpsychotomimetic phytocannabinoids
https://www.pnas.org/doi/10.1073/pnas.2416886122
308 Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy
https://www.science.org/doi/10.1126/scitranslmed.adk3690
307 Multiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target
https://www.sciencedirect.com/science/article/abs/pii/S0092867424010924
306 The Parkinson’s disease drug entacapone disrupts gut microbiome homeostasis via iron sequestration
https://www.nature.com/articles/s41564-024-01853-0
305 Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma
https://www.nature.com/articles/s41586-024-08224-z
304 Spatial proteomics identifies JAKi as treatment for a lethal skin disease
https://www.nature.com/articles/s41586-024-08061-0
303 Delayed low-dose oral administration of 4′-fluorouridine inhibits pathogenic arenaviruses in animal models of lethal disease
https://www.science.org/doi/10.1126/scitranslmed.ado7034
302 The limitation of lipidation: Conversion of semaglutide from once-weekly to once-monthly dosing
https://www.pnas.org/doi/10.1073/pnas.2415815121
301 Combatting melioidosis with chemical synthetic lethality
https://www.pnas.org/doi/10.1073/pnas.2406771121
300 Metformin decelerates aging clock in male monkeys
https://www.cell.com/cell/abstract/S0092-8674(24)00914-0
299 Glucose-sensitive insulin with attenuation of hypoglycaemia
https://www.nature.com/articles/s41586-024-08042-3
298 Insulin-inspired hippocampal neuron–targeting technology for protein drug delivery
https://www.pnas.org/doi/10.1073/pnas.2407936121
297 Sympathetic neuropeptide Y protects from obesity by sustaining thermogenic fat
https://www.nature.com/articles/s41586-024-07863-6
296 Metformin decelerates aging clock in male monkeys
https://www.sciencedirect.com/science/article/abs/pii/S0092867424009140?via%3Dihub
295 A general strategy for the synthesis of taxane diterpenes
https://www.nature.com/articles/s41586-024-07675-8
294 Semisynthetic guanidino lipoglycopeptides with potent in vitro and in vivo antibacterial activity
https://www.science.org/doi/10.1126/scitranslmed.abo4736
293 Piplartine attenuates aminoglycoside-induced TRPV1 activity and protects from hearing loss in mice
https://www.science.org/doi/10.1126/scitranslmed.adn2140
292 Early metformin treatment: An effective approach for targeting fragile X syndrome pathophysiology
https://www.pnas.org/doi/10.1073/pnas.2407546121
291 PhAI: A deep-learning approach to solve the crystallographic phase problem
https://www.science.org/doi/10.1126/science.adn2777
290 A Gram-negative-selective antibiotic that spares the gut microbiome
https://www.nature.com/articles/s41586-024-07502-0
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