Proteome

Articles:

111 Acyl-CoA binding protein for the experimental treatment of anorexia
https://www.science.org/doi/10.1126/scitranslmed.adl0715

110 Computational design of soluble and functional membrane protein analogues
https://www.nature.com/articles/s41586-024-07601-y

109 An all-atom protein generative model
https://www.pnas.org/doi/10.1073/pnas.2311500121

108 A billion years of evolution manifest in nanosecond protein dynamics
https://www.pnas.org/doi/10.1073/pnas.2318743121

107 Claudin-2 upregulation enhances intestinal permeability, immune activation, dysbiosis, and mortality in sepsis
https://www.pnas.org/doi/10.1073/pnas.2217877121

106 CRD: A de novo design algorithm for the prediction of cognate protein receptors for small molecule ligands
https://www.cell.com/structure/abstract/S0969-2126(23)00450-1

105 Bone morphogenetic protein 9 is a candidate prognostic biomarker and host-directed therapy target for sepsis
https://www.science.org/doi/10.1126/scitranslmed.adi3275

104 Organ aging signatures in the plasma proteome track health and disease
https://www.nature.com/articles/s41586-023-06802-1

103 AlphaFold predictions implicate the protein DONSON as a key player in vertebrate replication initiation.
https://www.science.org/doi/full/10.1126/science.adi3448

102 Accurate proteome-wide missense variant effect prediction with AlphaMissense.
https://www.science.org/doi/full/10.1126/science.adg7492

101 PIEZO2 and perineal mechanosensation are essential for sexual function.
https://www.science.org/doi/full/10.1126/science.adg0144

100 Enzyme function prediction using contrastive learning.
https://www.science.org/doi/10.1126/science.adf2465

99 Direct observation of motor protein stepping in living cells using MINFLUX.
https://www.science.org/doi/10.1126/science.ade2676

98 A mass spectrometry and dialysis method detects metabolite-protein interactions that help to control physiology.
https://www.science.org/doi/10.1126/science.abm3452

97 Rosetta design and machine learning generate protein fragments that assemble into a huge set of functional enzymes.
https://www.science.org/doi/10.1126/science.ade9434

96 Nanoscopy of single antifreeze proteins reveals that reversible ice binding is sufficient for ice recrystallization inhibition but not thermal hysteresis.
https://www.pnas.org/doi/10.1073/pnas.2212456120

95 Structure of monkeypox virus DNA polymerase holoenzyme.
https://www.science.org/doi/10.1126/science.ade6360

94 Bioengineered peptibodies as blockers of ion channels.
https://www.pnas.org/doi/10.1073/pnas.2212564119

93 Evolutionary-scale prediction of atomic level protein structure with a language model.
https://www.biorxiv.org/content/10.1101/2022.07.20.500902v2

92 Evolution and antiviral activity of a human protein of retroviral origin.
https://www.science.org/doi/10.1126/science.abq7871

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