25 De novo design of self-assembling helical protein filaments.
http://science.sciencemag.org/content/362/6415/705
24 ITGBL1 promotes chondrogenesis and protects joint cartilage from osteoarthritis by inhibiting integrin-extracellular matrix interaction.
http://stm.sciencemag.org/content/10/462/eaam7486
23 Programmable protein circuits in living cells.
http://science.sciencemag.org/content/361/6408/1252
22 A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family.
http://advances.sciencemag.org/content/4/9/eaau4640
21 Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution.
http://rspb.royalsocietypublishing.org/content/285/1886/20181656
20 Cell-Penetrating Peptide Mediates Intracellular Membrane Passage of Human Papillomavirus L2 Protein to Trigger Retrograde Trafficking.
https://www.cell.com/cell/fulltext/S0092-8674(18)30958-9
19 SIRT6 deficiency results in developmental retardation in cynomolgus monkeys.
https://www.nature.com/articles/s41586-018-0437-z
18 A deep proteome analysis of human serum reveals the relationship between disease and genetics.
http://science.sciencemag.org/content/361/6404/769
17 A distinct abundant group of microbial rhodopsins discovered using functional metagenomics.
https://www.nature.com/articles/s41586-018-0225-9?utm_source=Nature_community&utm_medium=Community_sites&utm_content=BenJoh-Nature-MultipleJournals-Mi
16 Efficient encapsulation of proteins with random copolymers.
http://www.pnas.org/content/115/26/6578
15 Loss of esophageal SPINK7 unleashes protease activity, impairs barrier function, and induces proinflammatory responses.
http://stm.sciencemag.org/content/10/444/eaap9736
14 A knock-in mutation in beclin 1 that increases autophagy in mice extends animal lifespan, improves healthspan, and also rescues early lethality in mice deficient in the anti-ageing protein klotho.
https://www.nature.com/articles/s41586-018-0162-7
13 Xenoprotein engineering via synthetic libraries.
http://www.pnas.org/content/115/23/E5298
12 Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.
https://www.nature.com/articles/s41586-018-0153-8
11 The histone demethylase KDM6B regulates temperature-dependent sex determination in a turtle species.
http://science.sciencemag.org/content/360/6389/645
10 A system that combines nanoscale synthesis and affinity ranking enables high-throughput screening of reaction conditions and bioactivity for a given protein target, accelerating the process of drug discovery.
https://www.nature.com/articles/s41586-018-0056-8
9 Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics.
https://pubs.acs.org/doi/10.1021/acscentsci.7b00612
8 A bound reaction intermediate sheds light on the mechanism of nitrogenase.
http://science.sciencemag.org/content/359/6383/1484
7 Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.
http://science.sciencemag.org/content/359/6383/eaaq0939
6 Light-activated protein interaction with high spatial subcellular confinement.
http://www.pnas.org/content/115/10/E2238
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