521 An RNA-adapting CRISPR–Cas system is coupled with amplification and sequencing steps to record, retrieve and analyse changes in the transcriptome of a bacterial cell over time.
https://www.nature.com/articles/s41586-018-0569-1
520 Discovery of widespread type I and type V CRISPR-Cas inhibitors.
http://science.sciencemag.org/content/362/6411/240
519 CRISPR-Cas12a inhibitors that block gene editing in human cells are identified.
http://science.sciencemag.org/content/362/6411/236
518 CRISPR-Mediated Programmable 3D Genome Positioning and Nuclear Organization.
https://www.cell.com/cell/fulltext/S0092-8674(18)31185-1
517 Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining.
http://science.sciencemag.org/content/361/6407/1126
516 Double-stranded RNA binding protein, Staufen, is required for the initiation of RNAi in coleopteran insects.
http://www.pnas.org/content/115/33/8334
515 MicroRNA-30c-5p modulates neuropathic pain in rodents.
http://stm.sciencemag.org/content/10/453/eaao6299
514 Apoptosis propagates through the cytoplasm as trigger waves.
http://science.sciencemag.org/content/361/6402/607
513 A system that targets DNA polymerase activity with CRISPR-guided nickases to provide genetic diversification at user-defined loci enables forward genetic approaches.
https://www.nature.com/articles/s41586-018-0384-8
512 Three-dimensional intact-tissue sequencing of single-cell transcriptional states.
http://science.sciencemag.org/content/361/6400/eaat5691
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