Molecular Biology


537  Obesity caused by loss of function of one gene copy can be rescued via CRISPR-mediated activation of the normal copy.

536  Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo.

535  Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.

534  Introns are mediators of cell response to starvation.

533  Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury.

532  LZTR1 is a regulator of RAS ubiquitination and signaling.

531  A DNA methylation reader complex that enhances gene transcription.

530  CDK12 regulates DNA repair genes by suppressing intronic polyadenylation.

529  Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion.

528  The authors use a machine-learning algorithm to predict the spectrum of CRISPR–Cas9-nuclease-mediated DNA repair outcomes at human genomic target sites.

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