9 By immunizing mice with a small synthetic metal-baring complex mimicking the active site of matrix metalloproteinases (MMPs), the authors have generated antibodies that bind and inhibit activated MMP2 and MMP9 in a manner analogous to the mechanism of action of tissue inhibitors of metalloproteinases. Targeting the active conformation of these MMPs is therapeutically effective in mouse models of inflammatory bowel disease.
http://www.nature.com/nm/journal/v18/n1/abs/nm.2582.html
8 Detection of KRAS Gene Mutations in Endoscopic Ultrasound-Guided Fine-Needle Aspiration Biopsy for Improving Pancreatic Cancer Diagnosis.
http://www.nature.com/ajg/journal/v106/n12/abs/ajg2011281a.html
7 Statins Are Associated With a Reduced Risk of Gastric Cancer: A Population-Based Case–Control Study.
http://www.nature.com/ajg/journal/v106/n12/abs/ajg2011277a.html
6 c-Met Is a Marker of Pancreatic Cancer Stem Cells and Therapeutic Target.
http://www.gastrojournal.org/article/S0016-5085(11)01157-7/abstract
5 Autophagy Suppresses Age-Dependent Ischemia and Reperfusion Injury in Livers of Mice.
http://www.gastrojournal.org/article/S0016-5085(11)01153-X/abstract
4 Loss of Caspase-8 Protects Mice Against Inflammation-Related Hepatocarcinogenesis but Induces Non-Apoptotic Liver Injury.
http://www.gastrojournal.org/article/S0016-5085(11)01220-0/abstract
3 Antibodies Against Tumor Necrosis Factor (TNF) Induce T-Cell Apoptosis in Patients With Inflammatory Bowel Diseases via TNF Receptor 2 and Intestinal CD14+ Macrophages.
http://www.gastrojournal.org/article/S0016-5085(11)01215-7/abstract
2 A Clinical Prediction Rule and Platelet Count Predict Esophageal Varices in Children.
http://www.gastrojournal.org/article/S0016-5085(11)01246-7/abstract
1 Nonsteroidal Anti-Inflammatory Drugs and Statins Have Chemopreventative Effects in Patients With Barrett's Esophagus.
http://www.gastrojournal.org/article/S0016-5085(11)01219-4/abstract
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