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57 Chronotherapy with a glucokinase activator profoundly improves metabolism in obese Zucker rats.

56 Dorzagliatin in drug-naïve patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial.

55 Dynamin deficiency causes insulin secretion failure and hyperglycemia.

54 Lactation improves pancreatic β cell mass and function through serotonin production.

53 In mouse studies, metformin treatment results in increased secretion of growth/differentiation factor 15 (GDF15), which prevents weight gain in response to high-fat diet, and GDF15-independent lowering of circulating blood glucose.

52 Habenular TCF7L2 links nicotine addiction to diabetes.

51 Treatment of type 2 diabetes with the designer cytokine IC7Fc.

50 Intensive Glucose Control in Patients with Type 2 Diabetes — 15-Year Follow-up.

49 Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy.

48 Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes.

47 Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus.

46 Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes.

45 Ionic liquids for oral insulin delivery.

44 Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes.

43 Smartphone-controlled optogenetically engineered cells enable semiautomatic glucose homeostasis in diabetic mice.

42 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes.

41 Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 5-Year Outcomes.

40 Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease.

39 The authors inject mouse pluripotent stem cells into pancreatogenesis-disabled rat blastocysts and thereby generate rats with mouse pancreata from which the islets, when transplanted into mice, can provide a long-term cure for symptoms of diabetes, without continuous immunosuppression.

38 Metformin Is Associated With Higher Relative Abundance of Mucin-Degrading Akkermansia muciniphila and Several Short-Chain Fatty Acid-Producing Microbiota in the Gut.

37 Closed-loop insulin delivery in inpatients with type 2 diabetes: a randomised, parallel-group trial.

36 Outpatient Glycemic Control with a Bionic Pancreas in Type 1 Diabetes.

35 Novel glucose-sensing technology and hypoglycaemia in type 1 diabetes.

34 Home Use of an Artificial Beta Cell in Type 1 Diabetes.

33 Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients.

32 Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis.

31 Outpatient Glycemic Control with a Bionic Pancreas in Type 1 Diabetes.

30 Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis.

29 Null Mutation in Hormone-Sensitive Lipase Gene and Risk of Type 2 Diabetes.

28 Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 3-Year Outcomes.

27 Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2.

26 Constitutive Activation of PKA Catalytic Subunit in Adrenal Cushing's Syndrome.

25 Growth hormone prevents the development of autoimmune diabetes.

24 Efficacy and safety of recombinant human parathyroid hormone (1—84) in hypoparathyroidism (REPLACE).

23 Low-dose interleukin 2 in patients with type 1 diabetes.

22 Combined Angiotensin Inhibition for the Treatment of Diabetic Nephropathy.

21 Transplantation of human islets without immunosuppression.

20 Restoration of the Unfolded Protein Response in Pancreatic β Cells Protects Mice Against Type 1 Diabetes.

19 Glucagon-like peptide-1 receptor imaging for the localisation of insulinomas: a prospective multicentre imaging study.

18 Reprogramming of Intestinal Glucose Metabolism and Glycemic Control in Rats After Gastric Bypass.

17 Plasmid-Encoded Proinsulin Preserves C-Peptide While Specifically Reducing Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes.

16 Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation.

15 Serum proteomics reveals systemic dysregulation of innate immunity in type 1 diabetes.

14 Rats given alcohol to simulate binge drinking exhibit the first signs of diabetes, a result of altered insulin action in the brain.

13 Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the βKlotho/FGFR1c Receptor Complex.

12 Sleep deficiency and out-of-synch circadian rhythms impair pancreatic insulin secretion, a possible precursor to metabolic syndrome and diabetes.

11 MicroRNA 135 Regulates HOXA10 Expression in Endometriosis.

10 Urine Steroid Metabolomics as a Biomarker Tool for Detecting Malignancy in Adrenal Tumors.

9 MicroRNAs in Thyroid Cancer.

8 Angiotensin II Signaling Promotes Follicle Growth and Dominance in Cattle.

7 Analysis of Fertility-Related Soluble Mediators in Human Uterine Fluid Identifies VEGF as a Key Regulator of Embryo Implantation.

6 Aldosterone-Producing Adenoma Formation in the Adrenal Cortex Involves Expression of Stem/Progenitor Cell Markers.

5 Depletion of Bhmt Elevates sonic hedgehog Transcript Level and Increases β-Cell Number in Zebrafish.

4 Calcium Insufficiency Accelerates Type 1 Diabetes in Vitamin D Receptor-Deficient Nonobese Diabetic (NOD) Mice.

3 Cadherin Engagement Protects Human β-Cells from Apoptosis.

2 Sirt1 Is a Regulator of Bone Mass and a Repressor of Sost Encoding for Sclerostin, a Bone Formation Inhibitor.

1 Dietary Phosphate Restriction Normalizes Biochemical and Skeletal Abnormalities in a Murine Model of Tumoral Calcinosis.

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